Medicographia N° 120 (Vol 36 – N° 3 – 2014)

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EDITORIAL

• Servier: looking to the future. Innovation-driven partnerships
  Servier : promesse d’avenir. Partenariats pour l’innovation
  E. Canet, P. Touchon, France

ONCOLOGY

IMMUNOMODULATION AND CANCER

• State of the Art – Cancer immunotherapy through checkpoint blockade:
  the future of cancer treatment – D. Pardoll, USA
• Targeting B7-H3 in cancer – S. Koenig, USA

EPIGENETICS AND CANCER

• State of the Art – Epigenetic defects in cancer – R. Chaligné, E. Heard, France
• “Clinical development of histone deacetylase inhibitors – M. Salcedo Magguilli, France

APOPTOSIS AND CANCER

• State of the Art – The roles of programmed cell death in tumor development and cancer therapy, – A. Strasser, Australia
• Acting on the BCL2 dependence of cancer cells – O. Geneste, France

CARDIOVASCULAR DISEASE

RNA INTERFERENCE AND CARDIOVASCULAR DISEASE

• State of the Art – MicroRNA control of heart development, disease, and
  regeneration –E. N. Olson, USA
• Developing microRNA therapeutics for cardiovascular disease – E. van Rooij, Netherlands

CARDIOVASCULAR DISEASE (continued)

RYANODINE CHANNELS AND HEART FAILURE

• State of the Art – The role of leaky ryanodine receptors in heart disease:
  a novel therapeutic target – A. R. Marks, USA
• Servier’s partnership with ARMGO Pharma: targeting heart failure by
  inhibiting cardiac RyR2 calcium leak – N. Villeneuve, E. Canet, J. P. Vilaine, France

INFLAMMATION AND CARDIOVASCULAR DISEASE

• State of the Art – Atherosclerosis and related ischemic diseases:
  inflammation, the mixed blessing – J. S. Silvestre, A. Tedgui, France
• Exploring interleukin-1b modulation in coronary and ischemic disease – J. C. Tardif, Canada

NEUROSCIENCE

IMPROVING COGNITION AND NEUROPLASTICITY

• AMPA receptor modulation for enhancing plasticity and treating europathology – G. Lynch, C. M. Gall, USAl

DIABETES

INNOVATING IN TYPE 2 DIABETES

• IMIDIA: a precompetitive consortium for the b cell – B. Thorens, Switzerland
• The role of TXNIP in the pathophysiology of diabetes and its
  vascular complications: a concise review – G. Leibowitz, A. Ktorza, E. Cerasi, Israel and France

SPECIAL FOCUS

SPECIAL FOCUS ON CHINA

• The SIMM-Servier partnership for drug discovery: looking back, looking forward – J. Ding, Y. Ye, China

A TOUCH OF FRENCH DESIGN

• Transgression and innovation: French contemporary architecture
  outside of France – P. Jodidio, Switzerland
• A revolution in design: reinventing our relationships with objects and interiors – M. Lehanneur, France