Servier: Looking to the future
Innovation-driven partnerships
Issue coordinated by Emmanuel Canet and Pascal Touchon
EDITORIAL
- Servier: looking to the future. Innovation-driven partnerships
Servier : promesse d’avenir. Partenariats pour l’innovation
E. Canet, P. Touchon, France
ONCOLOGY
IMMUNOMODULATION AND CANCER
- State of the Art – Cancer immunotherapy through checkpoint blockade:
the future of cancer treatment – D. Pardoll, USA - Targeting B7-H3 in cancer – S. Koenig, USA
EPIGENETICS AND CANCER
- State of the Art – Epigenetic defects in cancer – R. Chaligné, E. Heard, France
- “Clinical development of histone deacetylase inhibitors – M. Salcedo Magguilli, France
APOPTOSIS AND CANCER
- State of the Art – The roles of programmed cell death in tumor development and cancer therapy, – A. Strasser, Australia
- Acting on the BCL2 dependence of cancer cells – O. Geneste, France
CARDIOVASCULAR DISEASE
RNA INTERFERENCE AND CARDIOVASCULAR DISEASE
- State of the Art – MicroRNA control of heart development, disease, and
regeneration –E. N. Olson, USA - Developing microRNA therapeutics for cardiovascular disease – E. van Rooij, Netherlands
CARDIOVASCULAR DISEASE (continued)
RYANODINE CHANNELS AND HEART FAILURE
- State of the Art – The role of leaky ryanodine receptors in heart disease:
a novel therapeutic target – A. R. Marks, USA - Servier’s partnership with ARMGO Pharma: targeting heart failure by
inhibiting cardiac RyR2 calcium leak – N. Villeneuve, E. Canet, J. P. Vilaine, France
INFLAMMATION AND CARDIOVASCULAR DISEASE
- State of the Art – Atherosclerosis and related ischemic diseases:
inflammation, the mixed blessing – J. S. Silvestre, A. Tedgui, France - Exploring interleukin-1b modulation in coronary and ischemic disease – J. C. Tardif, Canada
NEUROSCIENCE
- AMPA receptor modulation for enhancing plasticity and treating europathology – G. Lynch, C. M. Gall, USAl
IMPROVING COGNITION AND NEUROPLASTICITY
DIABETES
INNOVATING IN TYPE 2 DIABETES
- IMIDIA: a precompetitive consortium for the b cell – B. Thorens, Switzerland
- The role of TXNIP in the pathophysiology of diabetes and its
vascular complications: a concise review – G. Leibowitz, A. Ktorza, E. Cerasi, Israel and France
SPECIAL FOCUS
SPECIAL FOCUS ON CHINA
- The SIMM-Servier partnership for drug discovery: looking back, looking forward – J. Ding, Y. Ye, China
A TOUCH OF FRENCH DESIGN
- Transgression and innovation: French contemporary architecture
outside of France – P. Jodidio, Switzerland - A revolution in design: reinventing our relationships with objects and interiors – M. Lehanneur, France